12. Below is the coding strand sequence of the first 300 bases in the normal HTT allele
(bottom rows) and the amino acids encoded by this sequence (top rows). Edit them to show the sequences of the disease version of the HTT allele and protein. (4 pts)
MetAlaThrLeuGluLysLeuMetLysAlaPheGluSerLeuLysSerPheGlnGlnGln
5’ atggcgaccctggaaaagctgatgaaggccttcgagtccctcaagtccttccagcagcag
GlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGln
cagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcaacag
ProProProProProProProProProProProGlnLeuProGlnProProProGlnAla
ccgccaccgccgccgccgccgccgccgcctcctcagcttcctcagccgccgccgcaggca
GlnProLeuLeuProGlnProGlnProProProProProProProProProProGlyPro
Cagccgctgctgcctcagccgcagccgcccccgccgccgcccccgccgccacccggcccg
AlaValAlaGluGluProLeuHisArgProLysLysGluLeuSerAlaThrLysLysGlu
gctgtggctgaggagccgctgcaccgaccaaagaaagaactttcagctaccaagaaagac
(bottom rows) and the amino acids encoded by this sequence (top rows). Edit them to show the sequences of the disease version of the HTT allele and protein. (4 pts)
MetAlaThrLeuGluLysLeuMetLysAlaPheGluSerLeuLysSerPheGlnGlnGln
5’ atggcgaccctggaaaagctgatgaaggccttcgagtccctcaagtccttccagcagcag
GlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGlnGln
cagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcagcaacag
ProProProProProProProProProProProGlnLeuProGlnProProProGlnAla
ccgccaccgccgccgccgccgccgccgcctcctcagcttcctcagccgccgccgcaggca
GlnProLeuLeuProGlnProGlnProProProProProProProProProProGlyPro
Cagccgctgctgcctcagccgcagccgcccccgccgccgcccccgccgccacccggcccg
AlaValAlaGluGluProLeuHisArgProLysLysGluLeuSerAlaThrLysLysGlu
gctgtggctgaggagccgctgcaccgaccaaagaaagaactttcagctaccaagaaagac
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