I tested ANA positive & anti SSA positive.

I tested ANA positive & anti-SSA positive. Dr. said time would tell if this was significant, & I decided to see another Rheumatologist. Based on these findings, pictures of rash on face, and my medical history, he performed tests. This time the ANA & anti-Ro were both negative. MRI showed tiny white spots on my brain. He feels very strongly that I have lupus & prescribed Plaquenil. I have mouth ulcers, fatigue, frequent headaches, anemia, achiness, some toes that go numb, started having high blood pressure (although cholesterol and weight are great) ,and have had a facial rash from sun several times (also swelling around eyes). How does the ANA & SSA suddenly test negative? What is your opinion or explanation?

Pls is there anyone that can help me in anyway? this is a dire situation for me, please help.

I can only recommend that you call your doctor's office and ask to speak to your doctor or a nurse in the office. Get them to answer your questions until you are satisfied that you understand. If that doesn't help, get a second opinion.